Avana 200 mg, which contains Avanafil, is a medication used to treat erectile dysfunction (ED). Like other medications, it can interact with various other drugs. Here are some key interactions to be aware of:

Nitrates: Avanafil should not be taken with nitrate medications (e.g., nitroglycerin, isosorbide dinitrate) used for heart conditions. The combination can cause a dangerous drop in blood pressure.

Alpha-blockers: Used for high blood pressure or prostate problems (e.g., tamsulosin, doxazosin), combining these with Avana 200 mg can also result in low blood pressure and dizziness.

Other PDE5 Inhibitors: Do not combine Avana 200 mg with other PDE5 inhibitors (such as Sildenafil, Tadalafil, or Vardenafil) to avoid overdose or increased risk of severe side effects.

Antihypertensives: Medications used to treat high blood pressure (e.g., beta-blockers, ACE inhibitors) can have additive effects with Avana 200 mg, leading to low blood pressure.

CYP3A4 Inhibitors: Medications that inhibit the enzyme CYP3A4 (e.g., certain antifungals like ketoconazole, antibiotics like erythromycin, HIV protease inhibitors like ritonavir) can increase Avana 200 mg levels in the blood, heightening the risk of side effects.

CYP3A4 Inducers: Conversely, drugs that induce CYP3A4 (e.g., rifampin, phenytoin, carbamazepine) can decrease Avanafil effectiveness by lowering its levels in the blood.

Alcohol: Drinking alcohol while taking Avanafil can increase the risk of side effects such as dizziness, headache, and low blood pressure.

Other Medications: Always inform your healthcare provider of all medications, including over-the-counter drugs and supplements, to ensure no harmful interactions occur.

It's crucial to consult with a healthcare provider before taking Avana 200 mg to review your current medications and medical conditions to avoid potential interactions and ensure safe use.